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IGF-1 signaling also plays a role in maintaining BBB integrity by promoting the expression of tight junction proteins and inhibiting the breakdown of the extracellular matrix (Freese et al., 2017)

Free Radic Biol Med 78:4255

I discuss these interventions in more detail in my first book, Hashimotos: The Root Cause , as well as in my second book, Hashimotos Protocol

Importantly, short-term treatment with rifampicin (4 h) did not reduce intracellular bacterial viability (Extended Data Fig

43% Less Melanin in 4 Weeks In-vitro tyrosinase enzyme assays demonstrated Kojic Acid (1% concentration) inhibited melanin synthesis by 43% in 4 weeks